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Description
Curcumin (diferuloylmethane) (C 21 H 20 O 6 ) is chemically [1, (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (Figure 1)

However, no activators targeting ARHGEF3 have been identified by far, developing of which targeting macrophages to increase infection resistance possesses a potential clinical implication
These theories focus on chemical imbalances in the brain, either through excess or deficiency of neurotransmitters such as dopamine, serotonin, and glutamate

Clinical impact of early brain atrophy in clinically isolated syndromes

*Correspondence: Haipeng Wang, [email protected]
