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Oxidative injury assessment Protein quantification was assessed as described by Lowry et al

We highlight recent progress in the discovery of selective inhibitors, dual-target inhibitors, allosteric modulators, covalent inhibitors, proteolysis-targeting chimeras (PROTACs), and protein-protein interaction (PPI) modulators

[18] constructed an osteoporosis model by ovariectomy and administered total flavonoids of Rhizoma drynariae (TFRD) via gavage to upregulate the mRNA expression levels of Wnt3, LRP-5, -catenin and Runx2, as well as the protein expression of Wnt3, LRP-5 and -catenin in the tibia tissue of rats with osteoporosis, thereby attenuating the structural damage of bone tissue

Vitamin C contributes to normal collagen formation, supporting firmness and elasticity, while intracellular GSH protects the extracellular matrix against oxidative degradation

doi: 10.1016/j.ebiom.2018.08.057 286 BockMSteffenFZippFBittnerS