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Over time, these combined effects of stress and environmental factors can result in a compromised skin barrier, decreased collagen production, and an overall loss of elasticity, contributing to a less vibrant and youthful appearance

[DOI] [PubMed] [Google Scholar] 120.Shibuya T., Fushimi N., Kawai M., Yoshida Y., Hachiya H., Ito S., Kawai H., Ohashi N., Mori A

10.1158/0008-5472.CAN-13-2922 [DOI] [PMC free article] [PubMed] [Google Scholar] Menassa M, Stronks K, Khatmi F, Roa Daz ZM, Espinola OP, Gamba M, Itodo OA, Buttia C, Wehrli F, Minder B, Velarde MR, Franco OH (2023) Concepts and definitions of healthy ageing: a systematic review and synthesis of theoretical models

doi: 10.1016/s0955-2863(03)00078-0