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Seminars in arthritis and rheumatism, 46 3, 319-329

Therefore, IC 80 value seems to be clinically more relevant in comparing NSAIDs inhibitory potencies against PGHS-1 and PGHS-2

Most of the research right now is preclinical with some early clinical data, so clinicians and patients should consider GHK-Cu a hopeful adjunct, not a sure bet therapy

Enhanced expression of GSH metabolism enzymes including glutathione peroxidases, gamma-glutamyl cysteinyl synthetase (gamma-GCS), glutathione S-transferases (GST), and ABC-family membrane transport proteins including the multidrug resistance-associated protein (MRP) were all documented to play prominent roles in cellular resistance to oxidative stress

42 Stage 1 symptoms are likely preclinical because the pathology is unlikely to cause long-term clinical manifestations at this point in the disease process