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Description
In inhaled delivery applications, PEG lipids may undergo size changes and aggregation upon nebulization 177 , and their effects on lipid hydration and membrane structure warrant consideration 178

Researchers still need more evidence before confirming whether low vitamin B12 directly contributes to cancer development

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As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5

astrocytes, microglia and infiltrating macrophages (9496)
