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HFL1(ATCC, CCL-153) cells were grown in DMEM/high glucose supplemented with 10% FBS, MEM Non-Essential Amino Acids Solution (Thermo Fisher Scientific,11140050), penicillin (100 U/mL), and streptomycin (100 mg/mL)

First, lactose intolerance is a large contributor to whey protein bloating

10.1016/s0169-409x(97)00063-x CrossRef Google Scholar View reference in article 9 BocsikA.GrfI.KissL.tvsF.ZsrosO.DarukaL.et al (2019)

The results indicated a significant improvement in H-Y grading within the experimental group compared to the control group (MD = 0.15, 95% CI [0.28, 0.01], p = 0.03), with no observed heterogeneity ( I 2 = 0%, p = 1.00) (Figure 15)

Furthermore, animal studies demonstrated that 12-day consecutive topical application of both (GA + Lico-A) micelles and Lico-A significantly attenuated UVB-induced hyperpigmentation in murine models, within MAPK/ERK pathway distribution patterns correlating precisely with areas of decreased tyrosinase activity (Wang et al., 2025)