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Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors
Neurons account for 75%80% of the brains energy consumption (Collier et al., 2023) and rely heavily on mitochondria, the primary producers of cellular energy, generating up to 95% of a eukaryotic cells ATP to support essential functions such as action potential generation, ion homeostasis, neurotransmitter cycling, and synaptic remodeling for learning and memory
[DOI] [PubMed] [Google Scholar] 165.Gao, K., Chen, Y., Mo, R
Several mechanistic considerations are of particular concern
