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No adverse events occurred in this study that were determined to be attributable to the treatments

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The implications of NNMT inhibition extend far beyond simple cofactor availability, influencing fundamental cellular processes including mitochondrial biogenesis, oxidative stress management, and epigenetic regulation

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They diverge in molecular stability, required administration route, mechanistic depth (particularly the beta3-adrenergic data for AOD-9604), and the weight of clinical evidence behind each