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Nature 583 (7816), 441446

Chronic diseases, such as kidney disease, may mask actual iron levels despite low ferritin

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Conclusions Changes in intra-portal insulin levels play an intricate yet permissive role in the regulation of the GH/IGF-I axis by either stimulating or suppressing hepatic GH sensitivity and hepatic IGF-I generation, probably via an insulin-mediated regulation of the hepatic GHR expression

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