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Description
The glutathione peroxidases
administered intratracheal instillation of NiO NPs (0.24 mg/kg body weight) to 16 male Wistar rats, twice a week for 9 weeks [37]

It is responsible for export of copper from hepatocytes
Additionally, Inflammatory factors, including TNF- and IL-6, inhibit tyrosine phosphorylation of insulin receptor substrates (IRS), thereby disrupting the insulin signaling pathway and diminishing insulin sensitivity

The other trial was conducted by Rizk et al
