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But there's and that's true

Cochrane Handbook for Systematic Reviews of Interventions, 205-228

Clinical Worsening and Suicide Risk Patients, their families, and their caregivers should be encouraged to be alert to the emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia (psychomotor restlessness), hypomania, mania, other unusual changes in behavior, worsening of depression, and suicidal ideation, especially early during antidepressant treatment and when the dose is adjusted up or down

Survival rates have significantly increased since the original studies, likely because of the utilization of prolonged NAC therapy and improved supportive care for patients with acute hepatic failure
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