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There are numerous reasons that B12 benefits those with autism including gastrointestinal abnormalities, diet, genetics, and more

Mood modulation and sleep quality has been associated with vitamin B12, so you may notice a reduction in symptoms of depression, anxiety, and insomnia due to the effectiveness of the injections

Having a lack of intrinsic factor (IF) , a substance that binds to B12 so it can be absorbed into the bloodstream (5)

Furthermore, excessive accumulation of NADH in conjunction with reduced NAD + availability can inhibit glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity in the glycolytic pathway, leading to glucose shunting to the glycolytic branch pathway (Yan et al., 2016
