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(3) additional details on how potential tools map to the individual drivers, as well as best practices

There are numerous studies in cell lines and animal models confirming the impact of oxidative stress during IRI in many organs 59,63,64,72,73,74

There were faster granulation tissue formation, re-epithelialization, dermal remodeling, and collagen deposition through extracellular signalregulated kinases (ERK)1/2 signaling pathway as well as its downstream targets, including c-Fos, c-Jun, and egr-1