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The levels of OS markers, including protein carbonyls, 4-hydroxy-2-non-enal (HNE), 3-nitrotyrosine (3-NT), and 8-OHdG, are increased in the blood and cerebrospinal fluid of patients with AD (172, 173)
Restriction of either Myc activity or mitochondrial substrates resulted in significant changes in the innate immune functions of dendritic cells, including reduced motility and T cell activation
This genotype-phenotype association is modulated by environmental factors such as sex, nutritional status, and metabolic disorders
