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Step 2 Conformational shift: Binding is thought to stabilize the receptorG-protein signaling complex, engaging Gq/11-coupled intracellular pathways in preclinical systems
CD38 reduces cellular NAD + levels, and therefore suppresses mitophagy by inhibiting the recruitment of damaged mitochondria to the phagophore through the SIRT1-PINK1-Parkin pathway
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doi: 10.1093/mmy/myw139, PMID: [DOI] [PubMed] [Google Scholar] 399
