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J Med Life 7(4):572576 Schwartz RA (2020) Which physical findings are characteristic of lentigines profusa

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In vitiligo, oxidative stress is associated with the accumulation of immature/misfolded proteins in the endoplasmic reticulum, which lowers the rate of protein synthesis, strengths the autophagic recycling and other degradative pathways, and activates the unfolded protein response (UPR) [50,51,52]

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