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Mol Biol Cell 24:115128

A regular exercise plan and a healthy diet are the foundation of any weight loss program, but sometimes a supplemental program treatment can give you an extra boost.

Published online July 31, 2025

Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau