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10.3346/jkms.2020.35.e293 56 LohaniS.GolenbiewskiJ.SwamiA.HalalauA

MND is a spectrum of neurodegenerative disorders leading to progressive muscle weakness and ultimately death secondary to respiratory failure

Proc Natl Acad Sci U S A 95:30716, PMID: 9501217 Won HY, Sohn JH, Min HJ, Lee K, Woo HA, Ho YS, Park JW, Rhee SG, Hwang ES (2010) Glutathione peroxidase 1 deficiency attenuates allergen-induced airway inflammation by suppressing Th2 and Th17 cell development

It encompasses a range of alterations in various metabolic pathways, including increased glucose uptake and lactate production even under aerobic conditions (aerobic glycolysis) [6], dependency on glutamine for anaplerosis and biosynthesis (glutaminolysis) [3], enhanced lipogenesis and altered fatty acid oxidation (lipid metabolism) [3], and changes in the metabolism of amino acids like serine and glycine [3]

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