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showed IGF-1 overexpression increased muscle mass 15-30% and improved strength in aged mice

Even though total body weights were similar on a normal chow diet, total WAT mass was reduced in HSL null mice compared to control and this difference was exaggerated on a high fat diet, with total WAT weight more than 70% lower in HSL null mice than in control

doi: 10.1016/j.jaci.2014.12.1924

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