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In primary hippocampal neuron cultures, Dihexa induces formation of functional excitatory synapses at sub-femtomolar concentrations making it approximately seven orders of magnitude more potent than BDNF and several orders of magnitude more potent than any other known synaptogenic molecule [1]

doi: 10.1164/rccm.2210007

H.WestermarkB.RichardsonW

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