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Thus, robust iron homeostasis, managed by networks involving transport (transferrin receptor, TfR), storage (ferritin), and export (ferroportin, FPN), works in concert with enzymatic antioxidants to prevent the initiation of the most damaging radical chain reactions, the failure of which is a direct pathway to ferroptosis [68, 69]

918 Inhibition of FOXO3a or oxidative stress reverses iron overload-induced muscle atrophy by reactivating the AKT-FOXO3a pathway

10.1126/science.1112085 177 LangerJ.RoseC

H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase

Omega-3 supplementation and stress reactivity of cellular aging biomarkers: an ancillary sub-study of a randomized, controlled trial in midlife adults
