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Here, a direct metabolic network-driven method that incorporates single gene essentiality and synthetic lethality predictions is proposed that generates a set of high-priority L

The enol form of the diketone is better stabilized due to charge delocalization and generates 1:2 and 1:3 type chelates with metal ions [89,90,91,92] (Figure 6)

Overexpression of TFEB leads to degradation of bulk autophagic substrates such as damaged mitochondria (Nezich et al., 2015), long-lived protein aggregates (Martini-Stoica et al., 2016), and lipid droplets (Settembre et al., 2013), indicating the crucial role of TFEB in organelle-specific autophagy, such as mitophagy and lipophagy (Settembre et al., 2013

Human genetic alterations lead to asymptomatic state of decreased GPX activity, GSSG reduction or NADPH supply (33)

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