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Epidermal axonal swellings in painful and painless diabetic peripheral neuropathy

668 This approach enhances therapeutic outcomes by aligning treatments with the patients genetic makeup

doi: 10.1007/s00401-016-1648-8 21

It plays integral roles in: Immune regulation Cancer suppression (anti-proliferative and pro-apoptotic signaling) Mitochondrial function and redox balance Hormonal feedback loops, including cortisol and estrogen/testosterone rhythms Aging diminishes melatonin output by up to 75%, leading to weaker circadian cues and downstream systemic dysfunction

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