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Various factors, including genetic and epigenetic mutations with increased drug efflux among others, contribute to drug resistance in cancer [179]
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10.3389/fcell.2019.00128 Front Cell Dev Biol
Moreover, rapamycin upregulated Wnt/-catenin signaling, including statistically significant upregulation of the T cell memory genes TCF7, LEF1, FOXO1 in rapamycin-treated products (Supplementary Data 5b)
