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Solomon DA, Nasinnyk KK

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A rise of 1C results in a 14% reduction in spermatogenesis (see Figure 4), leading to decreased sperm production [100]

Looking forward, several key research directions warrant urgent investigation: Spatiotemporal Dynamics of mtDNA Damage: Future studies should move beyond bulk tissue to map cell-type specific mtDNA mutations (e.g., exhausted CD8+ T cells vs
