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Proc Amer Assoc Cancer Res 47:4643, 2006

The concept of enhanced lactate production was first described a century ago by the Warburg effect, which revealed that tumor cells rely on anaerobic glycolysis even in the presence of oxygen, providing them with numerous advantages

Medulloblastoma: signalling a change in treatment

Studies in irradiated rat models demonstrated that copper tripeptide complex restored fibroblast function and collagen deposition in tissue where radiation had suppressed normal healing responses, a finding with potential implications for understanding repair biology in tissue with compromised vascularity

These results suggest that variant changes pre- and post-NAC are not associated with recurrence, indicating that the therapeutic pressure from NAC may have only a limited effect on the selection or elimination of specific tumor clones