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Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2

Following the differences in motor and non-motor behavior, and in serum levels of glucose, TH, -syn, and dopamine levels in the midbrain between Wt+R, and P479L+R mice, we examined the effect of the CPT1A P479L mutation on the gene expression levels of select targets in the midbrain of these mice using reverse transcriptase quantitative polymerase chain reaction (RT-qPCR)

1 2 The Cochrane Database of Systematic Reviews

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For this specific variant, temperature increases, such as having a fever, exposure to a sauna, or during heatstroke, can cause the CPT2 enzyme not to function
