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The fate of these fatty acids diverges critically: long-chain SFAs disrupt mitochondrial motility and impair axonal transport, while short-chain fatty acids (C12:0/C14:0) preserve mitochondrial integrity and support regeneration [173] (Fig
The liver is the major organ responsible for HDL clearance, and the entire HDL particle can enter the hepatocytes through an apo A1receptor interaction, where it undergoes a facilitated transfer of cholesterol and cholesterol esters to distinct pools within the cell
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J Inher Metab Dis 1999;22:442-87 35 -Scriver CR ea, eds, The Metabolic & Molecular Bases of Inherited Disease, 8 th Ed, Vol