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Its constituents, most notably the betalain pigments, display potent antioxidant, anti-inflammatory and chemo-preventive activity in vitro and in vivo

While early nonresponse is considered to be an indicator of later nonresponse and subsequent treatment resistance in schizophrenia [67], to our knowledge, the association between early nonresponse in first-episode samples and later sequential treatment failures and the status of conventionally defined TRS is yet to be established

Unfortunately, its effectiveness can be limited particularly during tumor recurrence by its toxicity to renal proximal tubule cells (reviewed in Zhang and Hanigan, 2003)

3.1.1 Indoxyl sulfate (IS) Indoxyl sulfate (IS) is classified as a protein-bound uremic toxin, with its biosynthesis originating from tryptophan metabolism: gut microbiota first convert tryptophan into indole, which is then transported to the liver for oxidation and sulfation to form IS (Wu et al., 2017)

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