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Adding spinal manipulation to supported self-management did not provide additional benefit

In addition to model resolution, the calibration factors for aerosol emission rates, the representation of aerosol size distributions, the quality and accuracy of input data, and the selection and implementation of parameterization schemes for various physical processes could all introduce uncertainties and potential impacts on the simulated results

10.1186/s13287-022-02963-4 133 LuJ.XuH.LiL.TangX.ZhangY.ZhangD.et al (2024)

Free radicals play critical role in generating oxidative stress, which oxidizes dopamine to dopamine quinone and superoxide anion and decreases the NADPH and dopamine metabolized by MOA that produces the 3,4-dihydroxyphenylacetaldehyde, ammonia, and H 2 O 2 , which in turn interacts with Fe ++ to generates the OH free radicals that kill neurons in PD [61, 62]

These fragments cause mitochondrial dysfunction and rearrangements in the cytoskeleton