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doi:10.1507/endocrj.EJ23-0380 Munari EV, Amer M, Amodeo A, et al

Synthesis of HaloRT probe HaloRT ligand (400 M, 200 L) was incubated with purified His-HaloTag protein (Promega, G4491, 6.5 mg/mL, 50L) for 1 h at room temperature in PBS

But this ignores that dose, delivery method, and context change everything, and that many of the peptides being sold are synthetic analogs rather than identical copies of what your body produces

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But on average people notice differences in their skin after 2-4 weeks of consistent use