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The majority of the functional LDH in mammalian cells contain various combinations two distinct types of LDH subunits, termed M (encoded by the LDHA gene) and H (encoded by the LDHB gene)
Based on these long-term exposure results, kava appeared to be well tolerated in rodents, particularly at a dosage not significantly higher than the human equivalent exposure

Guevara-Ramrez P, Cadena-Ullauri S, Ruiz-Pozo VA, Tamayo-Trujillo R, Paz-Cruz E, Simancas-Racines D, Zambrano AK
Jul 22 2020;21(15)doi:10.3390/ijms21155175
