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SAMe and B-vitamins co-supplementation reduced the NF-B (p65) DNA-binding activity in the liver and pancreas (Figures 14A,B), which may be attributable to improved antioxidant status and enhanced ROS neutralization, thereby potentially attenuating a key upstream driver of NF-B activation (Morgan and Liu, 2010)

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However, adipose tissue produces important pro-inflammatory cytokines, tumor necrosis factor, and inflammatory biomarkers, which are associated with body fat mass, suggesting that triggered innate immunity and inflammation factors in the pathogenesis of type 2 DM (Caton et al., 2013

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