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But the jump from C57BL/6 mice to humans involves differences in metabolic rate, NNMT tissue distribution, adipose tissue physiology, and drug metabolism that preclinical data cannot address

Animal studies report wide therapeutic windows

pharmacological inhibition of NNMT has therefore become a major focus in laboratory research on adipose-tissue energy balance, methyl-donor recycling, and metabolic resilience

Its history began with a breakthrough by a research team at the University of Texas, USA, in 2017.At that time, NNMT was recognized as a key enzyme in cellular metabolism and energy homeostasis, highly active in adipose tissue and closely linked to obesity, type 2 diabetes, and other metabolic diseases
