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Piezo1 impairs hepatocellular tumor growth via deregulation of the MAPK-mediated YAP signaling pathway
Operates at the nuclear protein-interaction level: Unlike metabolic or hormonal peptides that act on membrane receptors, FOXO4-DRI functions by disrupting nuclear protein interactions
A continued, unresolved imbalance between effector and regulatory immune responses further exacerbates inflammation that ultimately causes tissue and organ damage
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