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(2) Plasma-membrane lipid bilayer: ROS attacks membrane PUFAs, driving lipid peroxidation and generating cytotoxic aldehydes such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), which compromise membrane integrity and fluidity and impair motility/fertilization-related functions
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In line with this, a precision redox paradigm was introduced for the use of antioxidant pharmacology [112]
Oxidized glutathione must be regenerated by glutathione reductase to function as reduced glutathione
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