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Sirtuins Classification and Subcellular Localization Sirtuins (SIRTs), a family of class III histone deacetylases (HDACs), play crucial roles in various cellular processes and have significant implications for ageing and related diseases [1,2]

doi: 10.1021/cn5002914 54 KaliaL

It also helps to reduce inflammation, and supports the body's natural ability to fight off infection

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Thus, an increased Fe 2+ /Fe 3+ ratio and elevated levels of oxidized truncated phosphatidylcholines in CSF associate well with the ferroptotic signature observed in MS lesions