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For instance, it has been recently observed that in prostate cancer patients, polymorphism in GSTM3-3 may contribute to resistance to hormonal therapy through oxidative stress 45
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However, during the last decade, a new approach for the regulation of GSH-utilizing enzymes has emerged
Three human GLT25D/COLGALT isoforms have been identified: GLT25D1/COLGALT1, constitutively present in all human tissues, GLT25D2/COLGALT2, expressed mostly in nervous tissue, and GLT25D3/COLGALT3, found in all secretory tissues such as salivary glands, pancreas, placenta, as well as in the nervous system
Deficiency, common in regions with selenium-poor soil, slashes GPx expression, particularly GPx1, leading to heightened oxidative stress
