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This article compares selective CDK9 inhibition and degradation, emphasizing that while inhibition temporarily halts CDK9 activity, degradation offers a more persistent and potentially more effective therapeutic approach by eliminating the target protein entirely

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103 , 105 Recently, it was shown that GC-1 upregulated CPT1A transcription in human hepatocyte-derived huh-7 cell lines, indicating its ability to stimulate hepatic beta-oxidation

The research showed dose-dependent GH release while maintaining natural pulsatile secretion patterns

JCI Insight 5 (1), e131487