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However, the clinical persistence of EMS, a disease state characterized by impaired mitophagy, suggests that the resulting elevation in ROS is not sufficient to induce widespread EESC death

CYP450 Another family of enzymes involved in the metabolism of AA to eicosanoids, but also responsible for the metabolism of sterols, steroids, vitamin A, and vitamin D, are the enzymes from the cytochrome P450 (CYP450) family [131], which are also the most versatile class of enzymes metabolizing xenobiotics, including drugs, both in the liver and extrahepatically, including in the skin [131, 132]

misfolded proteins, it is certainly worthy of further assessment

10.7717/peerj.5509 98 VoetschB.JinR
