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doi: 10.2353/ajpath.2010.090682 89 RuggeriRMGiovinazzoSBarbalaceMCCristaniMAlibrandiAVicchioTMet al

During bulking periods, it can help limit fat gains and make a "cleaner" bulk

The following Taqman gene expression assays were used (Applied Biosystems catalogue numbers): mouse MAPT (Mm00521990_m1), GFAP (Mm01253030_m1), AIF1 (Mm00479862_g1), GRIA1 (Mm00433753_m1), TNF (Mm00443258_m1), CCL11 (Mm00441238_m1), TARDBP (Mm01257504_g1), and gene products were normalized to endogenous mouse GAPDH (Mm99999915_g1)

Interestingly, astrocytes (which protect neurons and promote sprouting) are activated because glial fibrillary acidic protein (GFAP) immunoreactivity increases in the striatum and indusium griseum upon METH treatment, thereby implying complex mechanisms involving guidance molecules and cytotoxic mediators in the neurotoxic consequences of METH (Ares-Santos et al., 2013

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