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Description
Variant calling was performed using the Genome Analysis Tool Kit (version 1.4) [26] followed by functional annotation using Annovar [27] and SnpEff [28]

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The use of glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor (GIPR/GLP-1R) agonists, such as tirzepatide, has been shown to improve glucose and lipid metabolism in T2DM patients, as measured by indirect calorimetry (40, 41)

Relationship of APOE, age at onset, amyloid and clinical phenotype in Alzheimer disease