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When glutamine levels are low, pyruvate carboxylase, a regulatory enzyme of gluconeogenesis, can allow fibroblasts to use extracellular lactate to maintain TCA cycle anaplerosis, non-essential amino acid biosynthesis, and extracellular matrix collagen production in the tumor microenvironment [73]
doi: 10.1016/j.jddst.2018.03.004
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Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4 + T cells
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