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The main mechanism of ferroptosis Inhibiting the cysteine-glutamate transporter system Xc can induce ferroptosis System Xc is a sodium independent antiporter that export intracellular glutamate and import extracellular cystine across the membrane in a ratio of 1:1 to synthesize glutathione in cells [19]

L-arginine plays a pivotal role in metabolic pathways encompassing pyrimidine metabolism, arginine biosynthesis, and the mammalian target of rapamycin (mTOR) signaling pathway

Excessive production of O 2 and its derivatives contributes to damage in cellular components such as lipid peroxidation, protein carbonylation, and DNA oxidation, thereby triggering inflammation and promoting disease progression [126]