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Peptide nootropics often meet these criteria more completely than synthetic nootropics, working with the brain's existing systems rather than forcing unnatural neurochemical states

Baseline reductions in structural connectivity also predict progression to poor cognitive outcomes at 3-year follow-up 141 and in PD patients with MCI they predict progression to dementia within 5 years 144 , with interhemispheric frontal and parietal connections being most implicated in cognitive impairment 141,144,145

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