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Other options that have been studied in patients with aggressive PRLomas include targeted oncological agents, such as everolimus (216, 217), bevacizumab (64, 218, 219), lapatinib (220, 221) and immune-checkpoint inhibitors (ipilimumab and nivolumab) (218, 219, 222, 223)

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Circadian rhythms are regulated by a coordinated network of oscillators, consisting of a central clock system and various peripheral clock systems