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IGFALS gene dosage effects on serum IGF-I and glucose metabolism, body composition, bone growth in length and width, and the pharmacokinetics of recombinant human IGF-I administration

Moreover, adeno-associated virus (AAV)-mediated PHGDH inactivation in the brain decreased tissue l-serine and glycine levels and impaired synaptic plasticity and spatial memory (60), demonstrating that reduced l-serine levels in the brain contribute to cognitive dysfunction

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Amino acid and protein modification by oxygen and nitrogen species
