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10.1016/j.neuropharm.2018.12.024 10

Cellular GSH reserves can be depleted in at least three different waysby increasing GSH oxidation, by inhibition of biosynthesis, or by inactivation of the genes encoding the enzymes of GSH synthesis

Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease

Cell 85 : 149158 Buschmann T, Potapova O, Bar-Shira A, Ivanov VN, Fuchs SY, Henderson S, Fried VA, Minamoto T, Alarcon-Vargas D, Pincus MR, Gaarde WA, Holbrook NJ, Shiloh Y and Ronai Z (2001) Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress

The well-known signaling mechanisms involve proteinprotein interactions, allosteric changes induced by the binding of ligands, proteolytic processing, and chemical modifications such as acylation, acetylation, alkylation, and phosphorylation of proteins
