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While latent GDF11 and GDF8 are known to be activated by the Tolloid proteases [Figure 2], which cleave the prodomains, activation can also be achieved under acid conditions in what is referred to as acid-activation [65]

Mov Disord 29:18021808 Simonyan K (2019) Recent advances in understanding the role of the basal ganglia [version 1

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HK2, the first catalytic enzyme involved in glucose metabolism, is enriched in primary human lung Fbs and upregulated in IPF patients