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Key Content and Findings Physiology of copper metabolism Copper (Cu) is a trace element essential in electron transfer reaction which is required for cellular respiration including handling of oxygen and free radicals (2)

Statistical analysis The SPSS 25.0 statistical package was used for statistical analysis

Moreover, ATM has been shown to promote G6PD activity and its inhibition compromises antioxidant responses [90, 91]

CYP1A1 has been shown to regulate intracellular iron levels and contribute to the production of ROS through the Fenton reaction

Dull under-eye skin is effectively revitalized by a complex of tranexamic acid and glutathione, which specifically targets signs of fatigue